http://dx.doi.org/10.1016/j.jinorgbio.2009.05.004">
 

Document Type

Journal Article

Department/Unit

Department of Chemistry

Title

Iron depletion decreases proliferation and induces apoptosis in a human colonic adenocarcinoma cell line, Caco2

Language

English

Abstract

Iron is essential for maintaining cellular metabolism of most organisms. Iron chelators such as desferrioxamine have been used clinically in the treatment of iron overload diseases. In the present study, we used human colon adenocarcinoma cells as a proliferating cell model to validate that desferrioxamine inhibits cell proliferation and induces apoptosis. Proteomic analysis revealed that proteins involved in cell proliferation, signal transduction, metabolism and protein synthesis were significantly regulated by the availability of iron, rendering a close correlation between cell apoptosis and the disturbance of mitochondrial, signaling and metabolic pathways. These results provide new insights into the mechanisms of cell proliferation inhibition attributed to iron depletion. © 2009 Elsevier Inc. All rights reserved.

Keywords

Anti-proliferation, Apoptosis, Caco2 cell, Desferrioxamine, Mitochondria

Publication Date

2009

Source Publication Title

Journal of Inorganic Biochemistry

Volume

103

Issue

7

Start Page

1074

End Page

1081

Publisher

Elsevier

ISSN (print)

01620134

ISSN (electronic)

18733344

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