http://dx.doi.org/10.1007/s11426-009-0233-6">
 

Document Type

Journal Article

Department/Unit

Department of Chemistry

Title

Recent progress in quantitative analysis of DNA adducts of nephrotoxin aristolochic acid

Language

English

Abstract

Aristolochic acid (AA), a mixture of structure-related nitrophenanthrene carboxylic acid derivatives derived from Aristolochia spp, is associated with nephrotoxin and carcinogen. AA-DNA adducts induced by reductive metabolic activation of AA were detected in tissues of animals and in patients exposed to AA. The DNA adducts were generally used as biomarkers in toxicological study of AA. In this short review, quantitative analysis of AA-DNA adducts in various in vitro and in vivo systems by using 32P-postlabelling assay, HPLC-UV, HPLC-radiation monitor, HPLC-FLD, HPLC-ESI/MS and UPLC-MS/MS methods is discussed. The distribution of AA-DNA adducts in various tissues is also summarized. © 2009 Science in China Press and Springer Berlin Heidelberg.

Keywords

Aristolochic acid, DNA adducts, Quantitative analysis, Short review

Publication Date

2009

Source Publication Title

Science in China Series B: Chemistry

Volume

52

Issue

10

Start Page

1576

End Page

1582

Publisher

Springer Verlag

ISSN (print)

10069291

ISSN (electronic)

18622771

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