Document Type

Journal Article

Department/Unit

Department of Chemistry

Title

Spiropyran-based optical approaches for mercury ion sensing: Improving sensitivity and selectivity via cooperative ligation interactions using cysteine

Language

English

Abstract

Spiropyrans are an attractive starting point in design of optical approaches for metal ions sensing. However, the high background in aqueous solution and non-specific chelation of the spiropyran with heavy metal ions has hindered their application as reliable sensors for environmental and biological species. Here, we report on a new spiropyran-based approach for sensitive and selective sensing of Hg2+ in aqueous solution, based on cooperative ligation interactions among the spiropyran probe, an intermediate, cysteine, and the metal ion. To test the feasibility of this design, three spiropyran scaffolds, L1-L3, with different ligation functions at the 8′-position were examined as model systems. The results demonstrate that by using cysteine, a potential ligand of Hg2+, the spiropyran could detect 1.0 × 10-7 M Hg2+ in aqueous solution. Due to the specific metal-amino acid interaction, the approach exhibits selective response toward Hg2+ over other metal ions and anions, although possible interference from Cu2+ has to be considered at the high level of the metal ion. This approach has been used for the determination of Hg2+ in water samples containing potential interferents with satisfactory recovery. © 2009 Elsevier B.V. All rights reserved.

Keywords

Cooperative interaction, Metal ions, Probe, Spiropyran

Publication Date

2009

Source Publication Title

Analytica Chimica Acta

Volume

655

Issue

2-1

Start Page

1

End Page

7

Publisher

Elsevier Masson

DOI

10.1016/j.aca.2009.09.038

Link to Publisher's Edition

http://dx.doi.org/10.1016/j.aca.2009.09.038

ISSN (print)

00032670

ISSN (electronic)

18734324

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