Department of Chemistry
Structure-based discovery of natural-product-like TNF-α inhibitors
(Figure Presented) Small but effective: Two natural-productlike inhibitors of tumor necrosis factor α (TNF-α represented in green in the picture) have been identified using structure-based virtual screening. These compounds represent only the third and fourth examples of direct targeting of TNF-α by a small molecule. and display potency comparable to that of the strongest TNF-α inhibitor reported to date. © 2010 Wiley-VCH Verlag GmbH & Co. KGaA.
Drug discovery, Inhibitors, Natural products, Tumor necrosis factor, Virtual screening
Source Publication Title
Angewandte Chemie International Edition
Link to Publisher's Edition
Chan, Daniel Shiu-Hin, Ho-Man Lee, Fang Yang, Chi-Ming Che, Catherine C. L. Wong, Ruben Abagyan, Chung-Hang Leung, and Ma. Dik-Lung. "Structure-based discovery of natural-product-like TNF-α inhibitors." Angewandte Chemie International Edition 49.16 (2010): 2860-2864.