Document Type

Journal Article

Department/Unit

Department of Chemistry

Title

Structure-based discovery of natural-product-like TNF-α inhibitors

Language

English

Abstract

(Figure Presented) Small but effective: Two natural-productlike inhibitors of tumor necrosis factor α (TNF-α represented in green in the picture) have been identified using structure-based virtual screening. These compounds represent only the third and fourth examples of direct targeting of TNF-α by a small molecule. and display potency comparable to that of the strongest TNF-α inhibitor reported to date. © 2010 Wiley-VCH Verlag GmbH & Co. KGaA.

Keywords

Drug discovery, Inhibitors, Natural products, Tumor necrosis factor, Virtual screening

Publication Date

2010

Source Publication Title

Angewandte Chemie International Edition

Volume

49

Issue

16

Start Page

2860

End Page

2864

Publisher

Wiley-VCH Verlag

DOI

10.1002/anie.200907360

Link to Publisher's Edition

http://dx.doi.org/10.1002/anie.200907360

ISSN (print)

14337851

ISSN (electronic)

15213773

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