http://dx.doi.org/10.1016/j.talanta.2008.10.022">
 

Document Type

Journal Article

Department/Unit

Department of Chemistry

Title

Studies on the aconitine-type alkaloids in the roots of Aconitum Carmichaeli Debx. by HPLC/ESIMS/MSn

Language

English

Abstract

Studies of aconitine-type alkaloids in the Chinese herb Aconitum Carmichaeli were performed by HPLC/ESIMS/MSn and FTICR/ESIMS in positive ion mode. The characteristic fragmentation pathways in the MSn spectra were summarized based on previously published research literature and further study. According to the fragmentation pathways of mass spectrometry, results from the analysis of standard compounds and reports from literature, 111 compounds were identified or deduced in a total of 117 found compounds in A. Carmichaeli. In the 11 monoester-diterpenoid alkaloids (MDA), 10 diesterditerpenoid alkaloids (DDA) and 81 lipo-alkaloids, the novel alkaloids including 1 MDA, 2 DDA and 48 lipo-alkaloids were detected. In addition, 1 DDA, 7 lipo-alkaloids and 2 alkaloids with small molecular weights that possess C19-norditerpenoid skeleton were reported in A. Carmichaeli for the first time. © 2008 Elsevier B.V. All rights reserved.

Keywords

Aconitine-type alkaloids, Aconitum Carmichaeli, C19-norditerpenoid, FTICR/ESIMS, HPLC/ESIMS/MSn

Publication Date

2009

Source Publication Title

Talanta

Volume

77

Issue

5

Start Page

1800

End Page

1807

Publisher

Elsevier

ISSN (print)

00399140

ISSN (electronic)

18733573

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