Department of Chemistry
A natural product-like inhibitor of NEDD8-activating enzyme
The natural product-like 6,6″-biapigenin has been identified as only the second inhibitor of NEDD8-activating enzyme using virtual screening. This compound was active in enzyme and cell-based assays, with potency in the micromolar range. © 2011 The Royal Society of Chemistry.
Source Publication Title
Royal Society of Chemistry
Leung, Chung-Hang, Daniel Shiu-Hin Chan, Hui Yang, Ruben Abagyan, Simon Ming-Yuen Lee, Guo-Yuan Zhu, Wang-Fun Fong, and Dik-Lung Ma. "A natural product-like inhibitor of NEDD8-activating enzyme." Chemical Communications 47.9 (2011): 2511-2513.