Document Type

Journal Article

Department/Unit

Department of Chemistry

Title

Comparison on gestation and lactation exposure of perfluorinated compounds for newborns

Language

English

Abstract

Perfluorinated compounds (PFCs) are worldwide present in the environment and the general population. Animal studies have shown developmental toxicity of these compounds. To investigate the PFCs exposure of neonates from mother during gestation and lactation, we analyzed twelve PFCs in matched maternal serum, cord serum and breast milk samples collected from 50 pairs of women and their newborns between June and July 2009 in Jinhu, China. Eight PFCs were detected in serum samples, and five of them were also detectable in breast milk. A significant intercorrelation between PFCs concentrations in matched maternal serum, cord serum and breast milk was observed (p. <. 0.01, r = 0.435-0.911). The median partition ratio was from 0.39:1 (PFDA) to 1.74:1 (PFTrDA) for seven PFCs through the placenta, and was from 0.02:1 (PFOS) to 0.09:1 (PFOA) for five PFCs through the lactation. A high transport efficiency of PFOA both through placental barrier and lactation was observed. The postnatal exposure of PFCs through lactation was higher compared to prenatal exposure, especially for PFOA. © 2011 Elsevier Ltd.

Keywords

Gestation exposure, Lactation exposure, Newborns, PFCs, PFOA, PFOS

Publication Date

2011

Source Publication Title

Environment International

Volume

37

Issue

7

Start Page

1206

End Page

1212

Publisher

Elsevier

DOI

10.1016/j.envint.2011.05.001

ISSN (print)

01604120

ISSN (electronic)

18736750

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