http://dx.doi.org/10.1002/elan.201000165">
 

Document Type

Journal Article

Department/Unit

Department of Chemistry

Title

Electrochemically induced free-radical polymerization for the fabrication of amperometric glucose biosensors

Language

English

Abstract

Electrochemically induced free radical polymerization was employed for the fabrication of amperometric glucose biosensors. Based on the electrochemical reduction of persulfate anion, an ultrathin poly(acrylic acid) (PAA) hydrogel coating was generated on both the bare and glucose oxidase (GOD) crosslinked platinum electrodes in a neutral phosphate buffer solution under a low ionic strength condition. This electrosynthetic approach offers a flexible and controllable way to prepare functional coatings for biosensors under a wide range of highly biocompatible conditions, significantly different from other electropolymerization technologies that usually cause the enzyme deactivation. Negatively charged PAA hydrogel coating not only results in a biosensor with good permselectivity and longterm stability, but also remarkably enhances its sensitivity by improving the oxygen recycle supply and the enzyme activity. Combined with a simple drop-evaporation procedure to control the GOD loading, the present method offers a versatile and biocompatible way for fabricating highly sensitive biosensor. © 2010 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Keywords

Acrylic acid, Amperometric glucose biosensor, Biosensors, Electrochemistry, Free radical polymerization, Hydrogel layer

Publication Date

2010

Source Publication Title

Electroanalysis

Volume

22

Issue

20

Start Page

2366

End Page

2375

Publisher

Wiley-VCH Verlag

ISSN (print)

10400397

ISSN (electronic)

15214109

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