Document Type

Journal Article

Department/Unit

Department of Chemistry

Title

Enantioselective preparation of ferrocenyl amino phosphines and their cytotoxic activities

Language

English

Abstract

In connection to our previously reported phosphine compounds as antitumor agents, this article describes the preparation of ferrocenyl amino-phosphine and their possible cytotoxic potential towards the human hepatocellular carcinoma cell line Hep3B. The preliminary results suggested that ferrocenyl amino-phosphines can be potential anti-tumour agents which might be considered as novel cancer chemotherapeutic agents. In particular, compounds 4b, 4d and 4f exhibit strong cytotoxicity with IC 50 < 5 μg ml -1. These compounds possess more promising cytotoxic activities than their precursor non-substituted ferrocene as well as the reference metallodrug cisplatin. © 2011 The Royal Society of Chemistry.

Publication Date

2011

Source Publication Title

MedChemComm

Volume

2

Issue

9

Start Page

881

End Page

885

Publisher

Royal Society of Chemistry

DOI

10.1039/C1MD00005E

Link to Publisher's Edition

http://dx.doi.org/10.1039/C1MD00005E

ISSN (print)

20402503

ISSN (electronic)

20402511

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