Department of Chemistry
Enantioselective preparation of ferrocenyl amino phosphines and their cytotoxic activities
In connection to our previously reported phosphine compounds as antitumor agents, this article describes the preparation of ferrocenyl amino-phosphine and their possible cytotoxic potential towards the human hepatocellular carcinoma cell line Hep3B. The preliminary results suggested that ferrocenyl amino-phosphines can be potential anti-tumour agents which might be considered as novel cancer chemotherapeutic agents. In particular, compounds 4b, 4d and 4f exhibit strong cytotoxicity with IC 50 < 5 μg ml -1. These compounds possess more promising cytotoxic activities than their precursor non-substituted ferrocene as well as the reference metallodrug cisplatin. © 2011 The Royal Society of Chemistry.
Source Publication Title
Royal Society of Chemistry
Kok, Stanton Hon-Lung, Wing-Sze Lam, Albert Sun-Chi Chan, Wai-Yeung Wong, Roberto Gambari, Raymond Siu-Ming Wong, Kenneth Ka-Ho Lee, Johnny Cheuk-On Tang, Kim-Hung Lam, and Chung-Hin Chui. "Enantioselective preparation of ferrocenyl amino phosphines and their cytotoxic activities." MedChemComm 2.9 (2011): 881-885.