Document Type

Journal Article

Department/Unit

Department of Chemistry

Title

Group 9 metal-based inhibitors of β-amyloid (1–40) fibrillation as potential therapeutic agents for Alzheimer's disease

Language

English

Abstract

We report here the first application of Group 9 metal complexes (i.e. iridium(III) and rhodium(III)) as inhibitors of amyloid fibrillogenesis and as luminescent probes for Aβ1-40 peptide. These complexes contained aromatic co-ligands to interact with the hydrophobic residues around the N-terminal domain of the Aβ1-40 peptide, as well as solvato co-ligands to allow coordinative bond formation with histidine residues. We demonstrate that these complexes could inhibit Aβ1-40 peptide aggregation in vitro, with potency superior to previous metal-based inhibitors reported. Furthermore, we have demonstrated the first example of luminescent detection of Aβ1-40 peptides by transition metal complexes. © The Royal Society of Chemistry 2011.

Publication Date

2011

Source Publication Title

Chemical Science

Volume

2

Issue

5

Start Page

917

End Page

921

Publisher

Royal Society of Chemistry

DOI

10.1039/C0SC00636J

Link to Publisher's Edition

http://dx.doi.org/10.1039/C0SC00636J

ISSN (print)

20416520

ISSN (electronic)

20416539

This document is currently not available here.

Share

COinS