Document Type

Journal Article

Department/Unit

Department of Chemistry

Title

In vitro imaging and human serum albumin responsive dimeric lanthanide DO3A complex

Language

English

Abstract

Two series of dimeric DO3A (1,4,7,10-tetraazacyclodecane-1,4,7-triacetate) lanthanide complexes (LnL1-LnL2, Ln = Eu, Gd, and Tb) have been synthesized with two different bridged chromophores. The X-ray structures of dimeric LnL1 (Ln = Gd and Tb) complexes show that each metal ion has nine coordination numbers with eight directly bound donor atoms of the ligand and one oxygen donor from the water molecule. Photophysical measurements indicate that the bridged antenna in LnL2 gives a higher efficiency than that of LnL1 and is responsive to the protein Human Serum Albumin (HSA), giving an f-f luminescence signal enhancement with a binding constant log K = 4.84. In vitro imaging of EuL1 and EuL2 in HeLa cells has been recorded, and EuL2 has demonstrated a higher rate of cellular uptake and low cytotoxicity (IC50 = 3 mM). © 2011 American Chemical Society.

Publication Date

2011

Source Publication Title

Inorganic Chemistry

Volume

50

Issue

12

Start Page

5517

End Page

5525

Publisher

American Chemical Society

DOI

10.1021/ic2004672

Link to Publisher's Edition

http://dx.doi.org/10.1021/ic2004672

ISSN (print)

00201669

ISSN (electronic)

1520510X

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