http://dx.doi.org/10.1002/anie.201006887">
 

Document Type

Journal Article

Department/Unit

Department of Chemistry

Title

Specific blocking of CREB/DNA binding by cyclometalated platinum(II) complexes

Language

English

Abstract

In the groove: The unique major-groove-binding properties of a Pt II complex can be used to block the interaction between the transcription factor CREB and DNA (see picture). Variation of the ligands around the Pt II center changes the DNA binding mode and results in specific gene regulators with superior potency and selectivity. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Keywords

bioinorganic chemistry, DNA recognition, metallodrugs, platinum, transcription factors

Publication Date

2011

Source Publication Title

Angewandte Chemie International Edition

Volume

50

Issue

11

Start Page

2554

End Page

2558

Publisher

Wiley-VCH Verlag

ISSN (print)

14337851

ISSN (electronic)

15213773

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