http://dx.doi.org/10.1002/cmdc.201100016">
 

Document Type

Journal Article

Department/Unit

Department of Chemistry

Title

Structure-based repurposing of FDA-approved drugs as TNF-α inhibitors

Language

English

Abstract

Old dogs, new tricks! We applied structure-based virtual screening methods to identify small-molecule inhibitors of tumor necrosis factor-α (TNF-α) from a database of 3000 US Food and Drug Administration (FDA)-approved drugs. Darifenacin (Enablex) and ezetimibe (Zetia) were identified as direct TNF-α inhibition, representing only the fifth and sixth examples of small-molecule TNF-α inhibitors. © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Keywords

Approved drugs, Drug discovery, Inhibitors, Tumor necrosis factor, Virtual screening

Publication Date

2011

Source Publication Title

ChemMedChem

Volume

6

Issue

5

Start Page

765

End Page

768

Publisher

Wiley-VCH Verlag

ISSN (print)

18607179

ISSN (electronic)

18607187

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