Department of Chemistry
A highly selective G-quadruplex-based luminescent switch-on probe for the detection of gene deletion
A G-quadruplex-based switch-on luminescence assay has been developed for the detection of gene deletion using a cyclometallated iridium(iii) complex as a G-quadruplex-selective probe. Upon hybridization with the target DNA, the two split G-quadruplex-forming sequences assemble into a split G-quadruplex, which greatly enhances the luminescence emission of the iridium(iii) probe. The assay is simple and highly selective. © 2012 The Royal Society of Chemistry.
Source Publication Title
Royal Society of Chemistry
He, Hong-Zhang, Daniel Shiu-Hin Chan, Chung-Hang Leung, and Dik-Lung Ma. "A highly selective G-quadruplex-based luminescent switch-on probe for the detection of gene deletion." Chemical Communications 48.76 (2012): 9462-9464.