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Document Type

Journal Article

Department/Unit

Department of Chemistry

Title

A highly selective G-quadruplex-based luminescent switch-on probe for the detection of gene deletion

Language

English

Abstract

A G-quadruplex-based switch-on luminescence assay has been developed for the detection of gene deletion using a cyclometallated iridium(iii) complex as a G-quadruplex-selective probe. Upon hybridization with the target DNA, the two split G-quadruplex-forming sequences assemble into a split G-quadruplex, which greatly enhances the luminescence emission of the iridium(iii) probe. The assay is simple and highly selective. © 2012 The Royal Society of Chemistry.

Publication Date

2012

Source Publication Title

Chemical Communications

Volume

48

Issue

76

Start Page

9462

End Page

9464

Publisher

Royal Society of Chemistry

ISSN (print)

13597345

ISSN (electronic)

1364548X

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