Document Type

Journal Article

Department/Unit

Department of Chemistry

Title

An ultrasensitive colorimeter assay strategy for p53 mutation assisted by nicking endonuclease signal amplification

Language

English

Abstract

A novel catalytic colorimetric assay assisted by nicking endonuclease signal amplification (NESA) was developed. With the signal amplification, the detection limit of the p53 target gene can be as low as 1 pM, which is nearly 5 orders of magnitude lower than that of other previously reported colorimetric DNA detection strategies based on catalytic DNAzyme. © 2011 The Royal Society of Chemistry.

Publication Date

2011

Source Publication Title

Chemical Communications

Volume

47

Issue

32

Start Page

9096

End Page

9071

Publisher

Royal Society of Chemistry

DOI

10.1039/c1cc13146j

Link to Publisher's Edition

http://dx.doi.org/10.1039/c1cc13146j

ISSN (print)

13597345

ISSN (electronic)

1364548X

This document is currently not available here.

Share

COinS