http://dx.doi.org/10.1016/j.bios.2011.04.057">
 

Document Type

Journal Article

Department/Unit

Department of Chemistry

Title

Application of hydrophobic palladium nanoparticles for the development of electrochemical glucose biosensor

Language

English

Abstract

An amperometric glucose biosensor based on an n-alkylamine-stabilized palladium nanoparticles (PdNPs)-glucose oxidase (GOx) modified glassy carbon (GC) electrode has been successfully fabricated. PdNPs were initially synthesized by a biphase mixture of water and toluene method using n-alkylamines (dodecylamine, C 12-NH 2 and octadecylamine, C 18-NH 2) as stabilizing ligands. The performance of the PdNPs-GOx/GC biosensor was studied by cyclic voltammetry. The optimum working potential for amperometric measurement of glucose in pH 7.0 phosphate buffer solution is -0.02V (vs. Ag/AgCl). The analytical performance of the biosensor prepared from C 18-PdNPs-GOx is better than that of C 12-PdNPs-GOx. The C 18-PdNPs-GOx/GC biosensor exhibits a fast response time of ca. 3s, a detection limit of 3.0μM (S/N=3) and a linear range of 3.0μM-8.0mM. The linear dependence of current density with glucose concentration is 70.8μAcm -2mM -1. The biosensor shows good stability, repeatability and reproducibility. It has been successfully applied to determine the glucose content in human blood serum samples. © 2011 Elsevier B.V.

Keywords

Amperometry, Glucose, Palladium nanoparticles

Publication Date

2011

Source Publication Title

Biosensors and Bioelectronics

Volume

26

Issue

11

Start Page

4619

End Page

4623

Publisher

Elsevier

ISSN (print)

09565663

ISSN (electronic)

18734235

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