Document Type

Journal Article

Department/Unit

Department of Chemistry

Title

Chiral sulfonimide as a brønsted acid organocatalyst for asymmetric friedel–crafts alkylation of indoles with imines

Language

English

Abstract

Binaphthyl-based chiral sulfonimide (CSI) is demonstrated for the first time to be an efficient, strong Brønsted acid in asymmetric organocatalysis. A series of CSIs were synthesized and screened in the asymmetric Friedel-Crafts alkylation of indoles with imines. Good to excellent yields and enantioselectivities have been achieved. It was proved that it was crucial to wash the CSI catalyst with HCl before use. © 2011 American Chemical Society.

Publication Date

2011

Source Publication Title

Journal of Organic Chemistry

Volume

76

Issue

17

Start Page

7141

End Page

7147

Publisher

American Chemical Society

DOI

10.1021/jo2011335

Link to Publisher's Edition

http://dx.doi.org/10.1021/jo2011335

ISSN (print)

00223263

ISSN (electronic)

15206904

This document is currently not available here.

Share

COinS