Department of Chemistry
Effect of Surface-functionalized Nanoparticles on the Elongation Phase of Beta-amyloid (l-40) Fibrillogenesis
The influence of nanoparticles of various sizes and surface functionalities on the self-assembling fibrillogenesis of beta-amyloid (1-40) peptide was investigated Functionalized nanoparticles including quantum dots and gold nanoparticles were co-incubated with monomeric Aβ 1-40 peptides under seed-mediated growth method to study their influences on the elongation phase of the fibrillogenesis It is observed that charge-to-surface area ratio of the nanoparticles and the functional moiety and electrostatic charges of the conjugated ligands on the particle surfaces took crucial regulatory role in the Aβ 1-40 fibrillogenesis © 2012 Elsevier Ltd.
Nanoparticle, Peptide, Self-assembly, Surface modification
Source Publication Title
Chan, Ho-Man, Lehui Xiao, Kai-Ming Yeung, See-Lok Ho, Dan Zhao, Wing-Hong Chan, and Hung-Wing Li. "Effect of Surface-functionalized Nanoparticles on the Elongation Phase of Beta-amyloid (l-40) Fibrillogenesis." Biomaterials 33.18 (2012): 4443-4450.