http://dx.doi.org/10.1016/j.biomaterials.2012.03.024">
 

Document Type

Journal Article

Department/Unit

Department of Chemistry

Title

Effect of Surface-functionalized Nanoparticles on the Elongation Phase of Beta-amyloid (l-40) Fibrillogenesis

Language

English

Abstract

The influence of nanoparticles of various sizes and surface functionalities on the self-assembling fibrillogenesis of beta-amyloid (1-40) peptide was investigated Functionalized nanoparticles including quantum dots and gold nanoparticles were co-incubated with monomeric Aβ 1-40 peptides under seed-mediated growth method to study their influences on the elongation phase of the fibrillogenesis It is observed that charge-to-surface area ratio of the nanoparticles and the functional moiety and electrostatic charges of the conjugated ligands on the particle surfaces took crucial regulatory role in the Aβ 1-40 fibrillogenesis © 2012 Elsevier Ltd.

Keywords

Nanoparticle, Peptide, Self-assembly, Surface modification

Publication Date

2012

Source Publication Title

Biomaterials

Volume

33

Issue

18

Start Page

4443

End Page

4450

Publisher

Elsevier

ISSN (print)

01429612

ISSN (electronic)

18785905

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