http://dx.doi.org/10.1002/anie.201104150">
 

Document Type

Journal Article

Department/Unit

Department of Chemistry

Title

Inhibition of beta-amyloid peptide aggregation by multifunctional carbazole-based fluorophores

Language

English

Abstract

Stopping aggregation: Carbazole-based cyanine fluorophores bind selectively to the Aβ (1-40) peptide and its aggregates which are responsible for causing Alzheimer's disease. One of these fluorophores, SLOH, exerts a strong inhibitory effect on Aβ (1-40) fibrillogenesis (see scheme) and can pass through the blood-brain barrier making it a potential therapeutic agent for Alzheimer's disease. © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Keywords

Alzheimer's disease, beta-amyloid peptide, fluorophores, inhibitors

Publication Date

2012

Source Publication Title

Angewandte Chemie International Edition

Volume

51

Issue

8

Start Page

1804

End Page

1810

Publisher

Wiley-VCH Verlag

ISSN (print)

14337851

ISSN (electronic)

15213773

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