Department of Chemistry
Inhibition of beta-amyloid peptide aggregation by multifunctional carbazole-based fluorophores
Stopping aggregation: Carbazole-based cyanine fluorophores bind selectively to the Aβ (1-40) peptide and its aggregates which are responsible for causing Alzheimer's disease. One of these fluorophores, SLOH, exerts a strong inhibitory effect on Aβ (1-40) fibrillogenesis (see scheme) and can pass through the blood-brain barrier making it a potential therapeutic agent for Alzheimer's disease. © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Alzheimer's disease, beta-amyloid peptide, fluorophores, inhibitors
Source Publication Title
Angewandte Chemie International Edition
Yang, Wanggui, Yi Wong, Olivia T. W. Ng, Li-Ping Bai, Daniel W. J. Kwong, Ya Ke, Zhi-Hong Jiang, Hung-Wing Li, Ken K. L. Yung, and Man Shing Wong. "Inhibition of beta-amyloid peptide aggregation by multifunctional carbazole-based fluorophores." Angewandte Chemie International Edition 51.8 (2012): 1804-1810.