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Document Type

Journal Article

Department/Unit

Department of Chemistry

Title

Inhibition of Janus kinase 2 by cyclometalated rhodium complexes

Language

English

Abstract

Cyclometalated rhodium complexes were synthesized and evaluated as JAK2 metal-based inhibitors. Complexes 1 and 2 inhibited JAK2 enzyme phosphorylation activity, reduced JAK2 autophosphorylation in cellulo and exhibited cytotoxicity towards HEL cancer cells. To our knowledge, these are the first two examples of metal-based inhibitors of JAK2. © 2012 The Royal Society of Chemistry.

Publication Date

2012

Source Publication Title

MedChemComm

Volume

3

Issue

6

Start Page

696

End Page

698

Publisher

Royal Society of Chemistry

ISSN (print)

20402503

ISSN (electronic)

20402511

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