Department of Chemistry
Inhibition of Janus kinase 2 by cyclometalated rhodium complexes
Cyclometalated rhodium complexes were synthesized and evaluated as JAK2 metal-based inhibitors. Complexes 1 and 2 inhibited JAK2 enzyme phosphorylation activity, reduced JAK2 autophosphorylation in cellulo and exhibited cytotoxicity towards HEL cancer cells. To our knowledge, these are the first two examples of metal-based inhibitors of JAK2. © 2012 The Royal Society of Chemistry.
Source Publication Title
Royal Society of Chemistry
Leung, Chung-Hang, Hui Yang, Victor Pui-Yan Ma, Daniel Shiu-Hin Chan, Hai-Jing Zhong, Ying-Wei Li, Wang-Fun Fong, and Dik-Lung Ma. "Inhibition of Janus kinase 2 by cyclometalated rhodium complexes." MedChemComm 3.6 (2012): 696-698.