Document Type

Journal Article

Department/Unit

School of Chinese Medicine

Abstract

In this study, we report the use of a cyclometalated luminescent iridium(III) complex for the visualization of thiols. The detection of glutathione (GSH) by complex 1 is achieved through the reduction of its phendione N^N donor, which influences the metal-to-ligand charge-transfer (MLCT) of the complex. Complex 1 produced a maximum threefold luminescence enhancement at 587 nm in response to GSH. The linear detection range of 1 for GSH is between 0.2 and 2 M equivalents of GSH, with a detection limit of 1.67 μM. Complex 1 also displays good selectivity for thiols over other amino acids.

Publication Year

2016

Journal Title

Science and Technology of Advanced Materials

Volume number

17

Issue number

1

Publisher

National Institute for Materials Science

First Page (page number)

109

Last Page (page number)

114

Referreed

1

DOI

10.1080/14686996.2016.1162081

ISSN (print)

14686996

Link to Publisher’s Edition

http://dx.doi.org/10.1080/14686996.2016.1162081

Keywords

Iridium(III) complex, chemosensor, thiols

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