Document Type

Journal Article

Department/ Unit

School of Chinese Medicine

Title

Palladium/silver-cocatalyzed tandem reactions of oxabenzonorbornadienes with substituted arylacetylenes: A simple method for the preparation of 1,2-diarylethanones and 1,2-diarylacetylenes

Abstract

The effective synthesis of 1,2-diarylethanones was achieved using palladium(II) acetate [Pd(OAc)2] and silver triflate (AgOTf) as cocatalysts from various oxabenzonorbornadiene derivatives and substituted arylacetylenes via tandem reactions under mild conditions. Exploration of the oxabenzonorbornadiene substrates showed that the 1,2-diarylacetylenes were obtained from adjacent alkoxy substituted oxabenzonorbornadiene derivatives. Preliminary mechanistic studies indicate that the AgOTf served as an indispensable catalyst, and the mechanism of the tandem reaction was proposed.

Publication Year

2015

Journal Title

Organometallics

Volume number

34

Issue number

17

Publisher

American Chemical Society

First Page (page number)

4318

Last Page (page number)

4322

Referreed

1

DOI

10.1021/acs.organomet.5b00551

ISSN (print)

02767333

Link to Publisher’s Edition

http://dx.doi.org/10.1021/acs.organomet.5b00551

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