Document Type

Journal Article

Department/ Unit

School of Chinese Medicine

Title

Immunosuppressive decalin derivatives from red yeast rice

Abstract

Five new decalin derivatives (15), together with two known compounds (6 and 7), were isolated from the ethyl acetate extract of red yeast rice. Their structures were elucidated by means of NMR and mass spectroscopic analyses. Monascusic lactone A (1) is the first reported naturally occurring decalin derivative possessing a spiro lactone at the C-1 position. The immunosuppressive effects of all these isolates (17) on human T cell proliferation were investigated, and all, especially monascusic acids B (2), C (3), D (4), and A (6) and heptaketide (7), suppressed human T cell proliferation in a dose-dependent manner from 10 to 100 μM. This is the first report on the immunosuppressive activity of decalin derivatives.

Publication Year

2012

Journal Title

Journal of Natural Products

Volume number

75

Issue number

4

Publisher

American Chemical Society

First Page (page number)

567

Last Page (page number)

571

Referreed

1

DOI

10.1021/np2007236

ISSN (print)

01633864

ESSN

15206025

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