School of Chinese Medicine
Antiresorptive drugs, alendronate and raloxifene, are effective in lowering bone mineral density (BMD) loss in postmenopausal women. However, long-term treatment may be associated with serious side effects. Our research group has recently discovered that a Chinese herbal formula, ELP, could significantly reduce BMD loss in animal and human studies. Therefore, the present study aimed to investigate the potential synergistic bone-protective effects of different herb-drug combinations using ovariectomized rats. To assess the efficacy of different combinations, the total BMD was monitored biweekly in the 8-week course of daily oral treatment. Bone microarchitecture, bone strength, and deoxypyridinoline level were also determined after 8 weeks. From our results, coadministration of ELP and raloxifene increased the total tibial BMD by 5.26% (2.5 mg/kg/day of raloxifene; P=0.014) and 5.94% (0.25 mg/kg/day of raloxifene; P=0.026) when compared with the respective dosage groups with raloxifene alone. Similar synergistic effects were also observed in BMD increase at distal femur (0.25 mg/kg/day; P=0.001) and reduction in urinary deoxypyridinoline crosslink excretion (2.5 and 0.25 mg/kg/day; both P=0.02). However, such interactions could not be observed in all alendronate-treated groups. Our data provide first evidence that ELP could synergistically enhance the therapeutic effects of raloxifene, so that the clinical dosage of raloxifene could be reduced.
Evidence-Based Complementary and Alternative Medicine
Hindawi Publishing Corporation
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Ko, Chun-Hay, Wing-Sum Siu, Hing-Lok Wong, Si Gao, Wai-Ting Shum, Ching-Po Lau, Sau-Wan Cheng, Jacqueline Chor-Wing Tam, Leung-Kim Hung, Kwok-Pui Fung, Clara Bik-San Lau, Quan-Bin Han, and Ping-Chung Leung. "In vivo study on the pharmacological interactions between a Chinese herbal formula ELP and anti-resorptive drugs to counteract osteoporosis." Evidence-Based Complementary and Alternative Medicine 2012 (2012): 203732-1-203732-11.