Document Type

Journal Article

Department/Unit

School of Chinese Medicine

Abstract

© 2016 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine. The biological redundancies in molecular networks of complex diseases limit the efficacy of many single drug therapies. Combination therapeutics, as a common therapeutic method, involve pharmacological intervention using several drugs that interact with multiple targets in the molecular networks of diseases and may achieve better efficacy and/or less toxicity than monotherapy in practice. The development of combination therapeutics is complicated by several critical issues, including identifying multiple targets, targeting strategies and the drug combination. This review summarizes the current achievements in combination therapeutics, with a particular emphasis on the efforts to develop combination therapeutics for complex diseases.

Publication Year

2016

Journal Title

Journal of Cellular and Molecular Medicine

Volume number

12

Issue number

20

Publisher

Public Library of Science

First Page (page number)

2231

Last Page (page number)

2240

Referreed

1

DOI

10.1111/jcmm.12930

ISSN (print)

15821838

Keywords

combination therapeutics, complex diseases, molecular network

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