School of Chinese Medicine
Aptamers, which can be screened via systematic evolution of ligands by exponential enrichment (SELEX), are superior ligands for molecular recognition due to their high selectivity and affinity. The interest in the use of aptamers as ligands for targeted drug delivery has been increasing due to their unique advantages. Based on their different OPEN ACCESS compositions and preparation methods, aptamer-functionalized targeted drug delivery systems can be divided into two main categories: aptamer-small molecule conjugated systems and aptamer-nanomaterial conjugated systems. In this review, we not only summarize recent progress in aptamer selection and the application of aptamers in these targeted drug delivery systems but also discuss the advantages, challenges and new perspectives associated with these delivery systems.
International Journal of Molecular Sciences
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This study was supported by the Hong Kong General Research Fund (HKBU12102914 to Ge Zhang) and the Faculty Research Grant of Hong Kong Baptist University (FRG2/12-13/027 to Ge Zhang).
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
Aptamer, Aptamer-functionalized targeted drug delivery systems, Aptamer-nanomaterial conjugated systems, Aptamer-small molecule conjugated systems, SELEX
Jiang, Feng, Biao Liu, Jun Lu, Fangfei Li, Defang Li, Chao Liang, Lei Dang, Jin Liu, Bing He, Shaikh Atik Badshah, Cheng Lu, Xiaojuan He, Baosheng Guo, Xiao-Bing Zhang, Weihong Tan, Aiping Lu, and Ge Zhang. "Progress and challenges in developing aptamer-functionalized targeted drug delivery systems." International Journal of Molecular Sciences 10.16 (2015): 23784-23822.