Document Type

Journal Article

Department/Unit

School of Chinese Medicine

Abstract

Aptamers, which can be screened via systematic evolution of ligands by exponential enrichment (SELEX), are superior ligands for molecular recognition due to their high selectivity and affinity. The interest in the use of aptamers as ligands for targeted drug delivery has been increasing due to their unique advantages. Based on their different OPEN ACCESS compositions and preparation methods, aptamer-functionalized targeted drug delivery systems can be divided into two main categories: aptamer-small molecule conjugated systems and aptamer-nanomaterial conjugated systems. In this review, we not only summarize recent progress in aptamer selection and the application of aptamers in these targeted drug delivery systems but also discuss the advantages, challenges and new perspectives associated with these delivery systems.

Publication Year

2015

Journal Title

International Journal of Molecular Sciences

Volume number

10

Issue number

16

Publisher

MDPI

First Page (page number)

23784

Last Page (page number)

23822

Referreed

1

Funder

This study was supported by the Hong Kong General Research Fund (HKBU12102914 to Ge Zhang) and the Faculty Research Grant of Hong Kong Baptist University (FRG2/12-13/027 to Ge Zhang).

DOI

10.3390/ijms161023784

ISBN (print)

16616596

ISBN (electronic)

14220067

ISSN (print)

16616596

Link to Publisher’s Edition

http://dx.doi.org/10.3390/ijms161023784

Copyright

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Keywords

Aptamer, Aptamer-functionalized targeted drug delivery systems, Aptamer-nanomaterial conjugated systems, Aptamer-small molecule conjugated systems, SELEX

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