Document Type

Journal Article

Authors

Feng Jiang, Institute for Advancing Translational Medicine in Bone and Joint Diseases, School of Chinese Medicine, Hong Kong Baptist UniversityFollow
Biao Liu, Institute for Advancing Translational Medicine in Bone and Joint Diseases, School of Chinese Medicine, Hong Kong Baptist UniversityFollow
Jun Lu, Institute for Advancing Translational Medicine in Bone and Joint Diseases, School of Chinese Medicine, Hong Kong Baptist UniversityFollow
Fangfei Li, Institute for Advancing Translational Medicine in Bone and Joint Diseases, School of Chinese Medicine, Hong Kong Baptist UniversityFollow
Defang Li, Institute for Advancing Translational Medicine in Bone and Joint Diseases, School of Chinese Medicine, Hong Kong Baptist UniversityFollow
Chao Liang, Institute for Advancing Translational Medicine in Bone and Joint Diseases, School of Chinese Medicine, Hong Kong Baptist UniversityFollow
Lei Dang, Institute for Advancing Translational Medicine in Bone and Joint Diseases, School of Chinese Medicine, Hong Kong Baptist UniversityFollow
Jin Liu, Institute for Advancing Translational Medicine in Bone and Joint Diseases, School of Chinese Medicine, Hong Kong Baptist UniversityFollow
Bing He, Institute for Advancing Translational Medicine in Bone and Joint Diseases, School of Chinese Medicine, Hong Kong Baptist UniversityFollow
Shaikh Atik Badshah, Institute for Advancing Translational Medicine in Bone and Joint Diseases, School of Chinese Medicine, Hong Kong Baptist UniversityFollow
Cheng Lu, Institute for Advancing Translational Medicine in Bone and Joint Diseases, School of Chinese Medicine, Hong Kong Baptist UniversityFollow
Xiaojuan He, Institute for Advancing Translational Medicine in Bone and Joint Diseases, School of Chinese Medicine, Hong Kong Baptist UniversityFollow
Baosheng Guo, Institute for Advancing Translational Medicine in Bone and Joint Diseases, School of Chinese Medicine, Hong Kong Baptist UniversityFollow
Xiao-Bing Zhang, Molecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering of Hunan University
Weihong Tan, Molecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering of Hunan University
Aiping Lu, Institute for Advancing Translational Medicine in Bone and Joint Diseases, School of Chinese Medicine, Hong Kong Baptist UniversityFollow
Ge Zhang, Institute for Advancing Translational Medicine in Bone and Joint Diseases, School of Chinese Medicine, Hong Kong Baptist UniversityFollow

Department/Unit

School of Chinese Medicine

Abstract

© 2015 by the authors; licensee MDPI, Basel, Switzerland. Aptamers, which can be screened via systematic evolution of ligands by exponential enrichment (SELEX), are superior ligands for molecular recognition due to their high selectivity and affinity. The interest in the use of aptamers as ligands for targeted drug delivery has been increasing due to their unique advantages. Based on their different OPEN ACCESS compositions and preparation methods, aptamer-functionalized targeted drug delivery systems can be divided into two main categories: aptamer-small molecule conjugated systems and aptamer-nanomaterial conjugated systems. In this review, we not only summarize recent progress in aptamer selection and the application of aptamers in these targeted drug delivery systems but also discuss the advantages, challenges and new perspectives associated with these delivery systems.

Publication Year

2015

Journal Title

International Journal of Molecular Sciences

Volume number

10

Issue number

16

Publisher

MDPI

First Page (page number)

23784

Last Page (page number)

23822

Referreed

1

DOI

10.3390/ijms161023784

ISSN (print)

16616596

Keywords

Aptamer, Aptamer-functionalized targeted drug delivery systems, Aptamer-nanomaterial conjugated systems, Aptamer-small molecule conjugated systems, SELEX

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