Document Type

Journal Article

Department/ Unit

School of Chinese Medicine

Abstract

© 2016 by the authors; licensee MDPI, Basel, Switzerland. Nucleic acids participate in a large number of biological processes. However, current approaches for small molecules targeting protein are incompatible with nucleic acids. On the other hand, the lack of crystallization of nucleic acid is the limiting factor for nucleic acid drug design. Because of the improvements in crystallization in recent years, a great many structures of nucleic acids have been reported, providing basic information for nucleic acid drug discovery. This review focuses on the discovery and development of small molecules targeting nucleic acids.

Publication Year

2016

Journal Title

International Journal of Molecular Sciences

Volume number

6

Issue number

17

Publisher

MDPI

Referreed

1

DOI

10.3390/ijms17060779

ISSN (print)

16616596

Keywords

DNA drug discovery, Nucleic acids, Nucleic acids targeting, RNA drug discovery, Small molecules

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