School of Chinese Medicine
© 2015 by the authors; licensee MDPI, Basel, Switzerland. Henrin A (1), a new ent-kaurane diterpene, was isolated from the leaves of Pteris henryi. The chemical structure was elucidated by analysis of the spectroscopic data including one-dimensional (1D) and two-dimensional (2D) NMR spectra, and was further confirmed by X-ray crystallographic analysis. The compound was evaluated for its biological activities against a panel of cancer cell lines, dental bacterial biofilm formation, and HIV. It displayed anti-HIV potential with an IC50 value of 9.1 µM (SI = 12.2).
International Journal of Molecular Sciences
First Page (page number)
Last Page (page number)
Anti-HIV activity, Bioactivity evaluation, Ent-kaurane diterpene, Henrin A, Pteris henryi
Li, Wan-Fei, Juan Wang, Jing-Jie Zhang, Xun Song, Chuen-Fai Ku, Juan Zou, Ji-Xin Li, Li-Jun Rong, Lu-Tai Pan, and Hong-Jie Zhang. "Henrin A: A new anti-HIV Ent-kaurane diterpene from Pteris henryi." International Journal of Molecular Sciences 11.16 (2015): 27978-27987.