Document Type

Journal Article

Department/Unit

School of Chinese Medicine

Abstract

Monoclonal antibodies are the dominant agents used in inhibition of biological target molecules for disease therapeutics, but there are concerns of immunogenicity, production, cost and stability. Oligonucleotide aptamers have comparable affinity and specificity to targets with monoclonal antibodies whilst they have minimal immunogenicity, high production, low cost and high stability, thus are promising inhibitors to rival antibodies for disease therapy. In this review, we will compare the detailed advantages and disadvantages of antibodies and aptamers in therapeutic applications and summarize recent progress in aptamer selection and modification approaches. We will present therapeutic oligonucleotide aptamers in preclinical studies for skeletal diseases and further discuss oligonucleotide aptamers in different stages of clinical evaluation for various disease therapies including macular degeneration, cancer, inflammation and coagulation to highlight the bright commercial future and potential challenges of therapeutic oligonucleotide aptamers.

Publication Year

2016

Journal Title

International Journal of Molecular Sciences

Volume number

17

Issue number

3

Publisher

MDPI

First Page (page number)

358

Referreed

1

Funder

This study was supported by the Hong Kong General Research Fund (HKBU262913 to Ge Zhang).

DOI

10.3390/ijms17030358

ISSN (print)

16616596

Link to Publisher’s Edition

http://dx.doi.org/10.3390/ijms17030358

Copyright

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Keywords

Clinical evaluation, Diseases therapy, Monoclonal antibodies, Oligonucleotide aptamers, Preclinical study

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