A luminescence switch-on probe for terminal deoxynucleotidyl transferase (TdT) activity detection by using an iridium(III)-based i-motif probe
Department of Chemistry
An iridium(III) complex exhibiting higher responce towards i-motif DNA over dsDNA and ssDNA was employed for the construction of a TdT activity detection platform. The assay exhibited a linear signal enhancement for TdT in the concentration range of 0 to 8 U mL−1, and the limit of detection for TdT was 0.25 U mL−1.
Source Publication Title
Royal Society of Chemistry
Link to Publisher's Edition
Lu, L., Wang, M., Liu, L., Wong, C., Leung, C., & Ma, D. (2015). A luminescence switch-on probe for terminal deoxynucleotidyl transferase (TdT) activity detection by using an iridium(III)-based i-motif probe. Chemical Communications, 51 (49). https://doi.org/10.1039/C5CC02790J