Document Type

Journal Article

Department/Unit

Department of Chemistry

Title

A luminescence switch-on probe for terminal deoxynucleotidyl transferase (TdT) activity detection by using an iridium(III)-based i-motif probe

Language

English

Abstract

An iridium(III) complex exhibiting higher responce towards i-motif DNA over dsDNA and ssDNA was employed for the construction of a TdT activity detection platform. The assay exhibited a linear signal enhancement for TdT in the concentration range of 0 to 8 U mL−1, and the limit of detection for TdT was 0.25 U mL−1.

Publication Date

6-30-2015

Source Publication Title

Chemical Communications

Volume

51

Issue

49

Start Page

9953

End Page

9956

Publisher

Royal Society of Chemistry

Peer Reviewed

1

DOI

10.1039/C5CC02790J

Link to Publisher's Edition

http://dx.doi.org/10.1039/C5CC02790J

ISSN (print)

13597345

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