Department of Chemistry
We report herein the application of kinetically inert luminescent iridium(III) complexes as dual inhibitors and probes of beta-amyloid fibrillogenesis. These iridium(III) complexes inhibited Aβ1–40 peptide aggregation in vitro, and protected against Aβ-induced cytotoxicity in neuronal cells. Furthermore, the complexes differentiated between the aggregated and unaggregated forms of Aβ1–40 peptide on the basis of their emission response.
Source Publication Title
Nature Publishing Group
Link to Publisher's Edition
Lu, L., Zhong, H., Wang, M., Ho, S., Li, H., Leung, C., & Ma, D. (2015). Inhibition of beta-amyloid fibrillation by luminescent iridium(III) complex probes. Scientific Reports, 5 (). https://doi.org/10.1038/srep14619