Document Type

Journal Article

Department/Unit

Department of Chemistry

Language

English

Abstract

We report herein the application of kinetically inert luminescent iridium(III) complexes as dual inhibitors and probes of beta-amyloid fibrillogenesis. These iridium(III) complexes inhibited Aβ1–40 peptide aggregation in vitro, and protected against Aβ-induced cytotoxicity in neuronal cells. Furthermore, the complexes differentiated between the aggregated and unaggregated forms of Aβ1–40 peptide on the basis of their emission response.

Publication Date

2015

Source Publication Title

Scientific Reports

Volume

5

Start Page

14619

Publisher

Nature Publishing Group

Peer Reviewed

1

DOI

10.1038/srep14619

Link to Publisher's Edition

http://dx.doi.org/10.1038/srep14619

ISSN (print)

20452322

Additional Files

JA-5034-28939_publisher_suppl.pdf (865 kB)

Included in

Chemistry Commons

Share

COinS