Document Type

Journal Article

Department/Unit

Department of Chemistry

Title

Recent developments in G-auadruplex probes

Language

English

Abstract

Accumulating evidence has linked G-quadruplex structures to a number of biological processes in vivo, including DNA replication, transcription, and genomic maintenance. However, the precise function and mechanism of G-quadruplex formation in mammalian cells remains poorly defined. Therefore, the development of small-molecule G-quadruplex probes has attracted significant attention in recent years. This review highlights examples of G-quadruplex probes that have been reported over the last few years, some of which have been employed for cellular imaging or for use in the construction of G-quadruplex-based analytical sensing platforms.

Publication Date

7-31-2015

Source Publication Title

Chemistry and Biology

Volume

22

Issue

7

Start Page

812

End Page

828

Publisher

Elsevier

Peer Reviewed

1

DOI

10.1016/j.chembiol.2015.06.016

Link to Publisher's Edition

http://dx.doi.org/10.1016/j.chembiol.2015.06.016

ISSN (print)

10745521

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