Document Type

Journal Article

Department/Unit

Department of Chemistry

Language

English

Abstract

A one-pot, two-step approach to prepare 2-tetrahydrofuran and -pyran substituted 1,3-dicarbonyl compounds by PhI=NTs-mediated amination/Brønsted base-catalyzed cross dehydrogenative coupling (CDC) reaction of the cyclic ether and 1,3-dicarbonyl derivative under mild conditions is reported. The reaction is compatible with a variety of cyclic ethers and 1,3-dicarbonyl compounds, affording the corresponding coupled products in moderate to good yields of up to 80% over two steps.

Keywords

C–C bond formation, cross dehydrogenation coupling, 1, 3-dicarbonyl compounds, iminoiodanes, metal-free catalysis

Publication Date

7-31-2015

Source Publication Title

Molecules

Volume

20

Issue

7

Start Page

13336

End Page

13353

Publisher

MDPI

Peer Reviewed

1

DOI

10.3390/molecules200713336

Link to Publisher's Edition

http://dx.doi.org/10.3390/molecules200713336

ISSN (print)

14203049

Additional Files

JA-5034-28943_publisher_suppl.pdf (2772 kB)

Included in

Chemistry Commons

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