Department of Chemistry
A G-pentaplex-based assay for Cs+ ions in aqueous solution using a luminescent Ir(III) complex
A series of 5 randomly designed in-house cyclometalated Ir(III) complexes were examined for their application in G-pentaplex probes and the “proof-of-principle” concept in G-pentaplex-based Cs+ ions detection. The G-pentaplex-forming sequence (DNA1, 5′-T(iG)4T-3′, where iG=isoguanine) is present in single strand DNA form ab initio, however, the addition of Cs+ ions lead to formation of the intermolecular G-pentaplex structure which is identified by the novel Ir(III) complex 1 afterward and produce an enhanced luminescence signal for Cs+ ions monitoring. To the best of our knowledge, this is the first G-pentaplex probe and also the first G-pentaplex-based label-free detection platform for Cs+ ions reported in the literature. The monitoring of spiked Cs+ ions in natural water samples demonstrates the potential application and technical sound of this “proof-of-principle” concept sensing platform.
Biosensors and Bioelectronics
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Label-free detection, Iridium(III) complex, G-pentaplex, Cs+
Lin, Sheng, Chao Yang, Zhifeng Mao, Bingyong He, Yi-Tao Wang, Chung-Hang Leung, and Dik Lung Ma. "A G-pentaplex-based assay for Cs+ ions in aqueous solution using a luminescent Ir(III) complex." Biosensors and Bioelectronics 77 (2016): 609-612.