Department of Chemistry
A novel dinuclear Ir(III) complex 5 was discovered to be specific to G-quadruplex DNA, and was utilized in a label-free G-quadruplex-based detection platform for transcription factor activity. The principle of this assay was demonstrated by using HIF-1α as a model protein. Moreover, this HIF-1α detection assay exhibited potential use for biological sample analysis.
Source Publication Title
Nature Publishing Group
Link to Publisher's Edition
Lu, L., Wang, M., Mao, Z., Kang, T., Chen, X., Lu, J., Leung, C., & Ma, D. (2016). A novel dinuclear iridium(III) complex as a G-quadruplex-selective probe for the luminescent switch-on detection of transcription factor HIF-1α. Scientific Reports, 6 (). https://doi.org/10.1038/srep22458