Document Type

Journal Article

Department/Unit

Department of Chemistry

Language

English

Abstract

A novel dinuclear Ir(III) complex 5 was discovered to be specific to G-quadruplex DNA, and was utilized in a label-free G-quadruplex-based detection platform for transcription factor activity. The principle of this assay was demonstrated by using HIF-1α as a model protein. Moreover, this HIF-1α detection assay exhibited potential use for biological sample analysis.

Publication Date

3-31-2016

Source Publication Title

Scientific Reports

Volume

6

Start Page

22458

Publisher

Nature Publishing Group

Peer Reviewed

1

DOI

10.1038/srep22458

Link to Publisher's Edition

http://dx.doi.org/10.1038/srep22458

ISSN (print)

20452322

Additional Files

JA-5034-28964_publisher_suppl.pdf (1053 kB)

Included in

Chemistry Commons

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