Utilization of G-quadruplex-forming aptamers for the construction of luminescence sensing platforms
Department of Chemistry
Aptamers are nucleic acid sequences that can recognize and bind to analytes with high affinity and selectivity. Intriguingly, a number of aptamers undergo a conformational change within the G-quadruplex motif upon ligand binding. This Minireview aims to highlight interesting examples of luminescent G-quadruplex aptamer-based probes that have been developed in recent years. Various mechanisms and sensing modes are described, and the outlook and future directions of this field are also discussed.
aptamers, G-quadruplexes, luminescence, oligonucleotides, sensors
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Ma, D., Wang, W., Mao, Z., Kang, T., Han, Q., Chan, P., & Leung, C. (2017). Utilization of G-quadruplex-forming aptamers for the construction of luminescence sensing platforms. ChemPlusChem, 81 (1). https://doi.org/10.1002/cplu.201600036