Department of Chemistry
Utilization of G-quadruplex-forming aptamers for the construction of luminescence sensing platforms
Aptamers are nucleic acid sequences that can recognize and bind to analytes with high affinity and selectivity. Intriguingly, a number of aptamers undergo a conformational change within the G-quadruplex motif upon ligand binding. This Minireview aims to highlight interesting examples of luminescent G-quadruplex aptamer-based probes that have been developed in recent years. Various mechanisms and sensing modes are described, and the outlook and future directions of this field are also discussed.
aptamers, G-quadruplexes, luminescence, oligonucleotides, sensors
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Link to Publisher's Edition
Ma, Dik Lung, Wanhe Wang, Zhifeng Mao, Tian-Shu Kang, Quanbin Han, Philip Wai Hong Chan, and Chung-Hang Leung. "Utilization of G-quadruplex-forming aptamers for the construction of luminescence sensing platforms." ChemPlusChem 81.1 (2017): 8-17.