Document Type

Journal Article

Title

Structure-based screening and optimization of cytisine derivatives as inhibitors of the menin–MLL interaction

Department/Unit

Department of Chemistry

Language

English

Abstract

The natural product-like compound 1 was identified as a direct inhibitor of the menin–MLL interaction by in silico screening. Structure-based optimization furnished analogue 1a, which showed significantly higher potency than both the lead structure 1 and the reference compound MI-2.

Publication Date

3-31-2016

Source Publication Title

Chemical Communications

Volume

52

Issue

34

Start Page

5788

End Page

5791

Publisher

Royal Society of Chemistry

Peer Reviewed

1

DOI

10.1039/C6CC01079B

Link to Publisher's Edition

http://dx.doi.org/10.1039/C6CC01079B

ISSN (print)

13597345

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