Department of Chemistry
Structure-based screening and optimization of cytisine derivatives as inhibitors of the menin–MLL interaction
The natural product-like compound 1 was identified as a direct inhibitor of the menin–MLL interaction by in silico screening. Structure-based optimization furnished analogue 1a, which showed significantly higher potency than both the lead structure 1 and the reference compound MI-2.
Source Publication Title
Royal Society of Chemistry
Link to Publisher's Edition
Zhong, Hai-Jing, Bo Ra Lee, Joshua William Boyle, Wanhe Wang, Dik Lung Ma, Philip Wai Hong Chan, and Chung-Hang Leung. "Structure-based screening and optimization of cytisine derivatives as inhibitors of the menin–MLL interaction." Chemical Communications 52.34 (2016): 5788-5791.