Structure-based screening and optimization of cytisine derivatives as inhibitors of the menin–MLL interaction
Department of Chemistry
The natural product-like compound 1 was identified as a direct inhibitor of the menin–MLL interaction by in silico screening. Structure-based optimization furnished analogue 1a, which showed significantly higher potency than both the lead structure 1 and the reference compound MI-2.
Source Publication Title
Royal Society of Chemistry
Link to Publisher's Edition
Zhong, H., Lee, B., Boyle, J., Wang, W., Ma, D., Chan, P., & Leung, C. (2016). Structure-based screening and optimization of cytisine derivatives as inhibitors of the menin–MLL interaction. Chemical Communications, 52 (34). https://doi.org/10.1039/C6CC01079B