Department of Chemistry
Epigenetic mechanisms have emerged as key targets for therapeutic intervention. However, while a number of organic small-molecular “epidrugs” have been approved for clinical use, no metal-based epigenetic modulator have been successfully approved. Metal complexes exhibit a variety of distinct properties that make them viable alternatives to organic molecules as therapeutic agents. In this review, we highlight recent examples of epigenetic modulation by metal complexes, with a view towards showcasing the different mechanisms exploited by metal complexes for targeting either epigenetic marks or epigenetic pathways for potential therapeutic applications.
Transition metal complexes, Epigenetic, Epidrugs, Histone, Chromatin-modifying enzymes
Source Publication Title
Coordination Chemistry Reviews
Link to Publisher's Edition
Leung, C., Liu, L., Leung, K., & Ma, D. (2016). Epigenetic modulation by inorganic metal complexes. Coordination Chemistry Reviews, 319 (). https://doi.org/10.1016/j.ccr.2016.03.014