Document Type

Journal Article

Department/Unit

Department of Chemistry

Language

English

Abstract

Epigenetic mechanisms have emerged as key targets for therapeutic intervention. However, while a number of organic small-molecular “epidrugs” have been approved for clinical use, no metal-based epigenetic modulator have been successfully approved. Metal complexes exhibit a variety of distinct properties that make them viable alternatives to organic molecules as therapeutic agents. In this review, we highlight recent examples of epigenetic modulation by metal complexes, with a view towards showcasing the different mechanisms exploited by metal complexes for targeting either epigenetic marks or epigenetic pathways for potential therapeutic applications.

Keywords

Transition metal complexes, Epigenetic, Epidrugs, Histone, Chromatin-modifying enzymes

Publication Date

2016

Source Publication Title

Coordination Chemistry Reviews

Volume

319

Start Page

25

End Page

34

Publisher

Elsevier

Peer Reviewed

1

DOI

10.1016/j.ccr.2016.03.014

Link to Publisher's Edition

http://dx.doi.org/10.1016/j.ccr.2016.03.014

ISSN (print)

00108545

Available for download on Wednesday, August 01, 2018

Included in

Chemistry Commons

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