Department of Chemistry
Fonsecin B has been identified as stabilizing ligand of c-mycG-quadruplexDNA using high-throughput virtual screening of a natural product database, and inhibited Taq polymerase-mediated DNA extension in vitro through stabilization of the G-quadruplex secondary structure.
Source Publication Title
Royal Society of Chemistry
Link to Publisher's Edition
Lee, Ho-Man, Daniel Shiu-Hin Chan, Fang Yang, Ho-Yu Lam, Siu-Cheong Yan, Chi-Ming Che, Dik-Lung Ma, and Chung-Hang Leung. "Identification of natural product Fonsecin B as a stabilizing ligand of c-myc G-quadruplex DNA by high-throughput virtual screening." Chemical Communications 46.26 (2010): 4680-4682.