Department of Chemistry
Fonsecin B has been identified as stabilizing ligand of c-mycG-quadruplexDNA using high-throughput virtual screening of a natural product database, and inhibited Taq polymerase-mediated DNA extension in vitro through stabilization of the G-quadruplex secondary structure.
Source Publication Title
Royal Society of Chemistry
Link to Publisher's Edition
Lee, H., Chan, D., Yang, F., Lam, H., Yan, S., Che, C., Ma, D., & Leung, C. (2010). Identification of natural product Fonsecin B as a stabilizing ligand of c-myc G-quadruplex DNA by high-throughput virtual screening. Chemical Communications, 46 (26). https://doi.org/10.1039/B926359D