Author

Chen Xie

Year of Award

8-30-2017

Degree Type

Thesis

Degree Name

Master of Philosophy (MPhil)

Department

Department of Chemistry.

Principal Supervisor

Wong, Ka Leung

Keywords

Cancer; Diagnosis; Luminescent probes; Nasopharynx; Treatment

Language

English

Abstract

On the purpose of designing a novel generation of luminescent bioprobes for imaging and inhibition of tumour cells, a series of lanthanide-ruthenium complexes has been synthesized and characterized by 1H NMR, 13C NMR, absorption/emission spectroscopy, high-performance liquid chromatography, and mass spectroscopy. Those complexes are qualified to be considered as photo-activatable anticancer prodrugs which consist of a ruthenium (II) complex linked to a lanthanide-based cyclen chelate via a π-conjugated bridge. Comprehensive studies have been performed to evaluate their efficacy as pro-drugs which requires in cellulo activity, inhibiting ability, instant monitoring possibility, and safety to normal cells. The resulting complexes are proved to be promising agents for controllable anticancer therapy because the prodrug remains inactive in dark and the release of the active drug is induced by visible light. Drug delivery process can be quantitatively monitored by either the long-lived red europium emission under one- or two-photon excitation or potentially by magnetic resonance imaging signals. Besides of these, the correlation among the drug releasing amount, signaling emission intensity, and mass spectroscopy response, has been proposed for quick and simple quantitative analysis.

Comments

Principal supervisor: Doctor Wong Ka-Leung. Thesis submitted to the Department of Chemistry.; Thesis (M.Phil.)--Hong Kong Baptist University, 2017.

Bibliography

Includes bibliographical references (pages 64-65).

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