Year of Award


Degree Type


Degree Name

Doctor of Philosophy (PhD)


Department of Chemistry.

Principal Supervisor

Leung, Ken Cham-fai


molecular switching ; Rotaxanes ; Catalysis ; Macromolecules




Type III-B rotaxane dendrimers (T3B-RDs) are hyperbranched macromolecules with mechanical bonds on every branching unit. First to third (G1-G3), and up to the fourth (G4) generation (MW>22,000 Da) of pure organic T3B-RDs and dendrons were successfully synthesized through the copper catalyzed alkyne-azide cycloaddition (CuAAC) reaction. By utilizing multiple molecular shuttling of the mechanical bonds within the sphere-like macromolecule, a collective three-dimensional contract-extend molecular motion was demonstrated by diffusion ordered spectroscopy (DOSY). The discrete T3B-RDs were further observed and characterized by atomic force microscopy (AFM), dynamic light scattering (DLS), and mass spectrometry (MS). The binding of chlorambucil and pH-triggered switching of the T3B-RDs were also characterized by 1H NMR spectroscopy.;Type III-C rotaxane dendrimer is a new type of rotaxane dendrimer where in the mechanical bonds are in between and constituing the branchning point to form the macromolecules. First and second (G1-G2) type III-C rotaxane dendrimers were synthesized successfully as a prototypical example. Two different shuttling processes have been deomostrated by the non-methylated and methylated type III-C rotaxane dendrimers, and characterized by 1H NMR spectroscopy.


Thesis submitted to the Department of Chemistry ; Principal supervisor: Doctor Leung Ken Cham Fai ; Thesis (Ph.D.)--Hong Kong Baptist University, 2018.


Includes bibliographical references.

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