Year of Award

7-14-2020

Degree Type

Thesis

Degree Name

Master of Philosophy (MPhil)

Department

Department of Physics

Principal Supervisor

Zhou, Changsong

Keywords

Brain ; Imaging ; Wakefulness ; Anesthesia

Language

English

Abstract

Consciousness and loss of consciousness is something we encounter in our everyday lives. Despite its commonplace in everyday life, scientists are still trying to understand and find reliable markers for it. In this work we use a data-driven K-means clustering approach to uncover the different functional patterns associated with different consciousness levels. We pursue this study using a high resolution optogenetic voltage image of the mouse brain waking up from anesthesia. The main questions we addressed in this study are: Can we identify signatures of conscious and unconsciousness from functional connectivity patterns? What is the nature of the different patterns that correspond to wakefulness and anesthesia? What is the nature of dynamics between these functional patterns in wakefulness and anesthesia? How does the anatomical connectivity support the observed functional patterns in wakefulness and anesthesia? Our results show that during anesthesia, the brain is characterized by a single dominant brain pattern with short range connections. Furthermore, we observed from our results that during anaesthesia the brain is characterized by minimal temporal exploration of the different brain configurations. Conversely, in awake state we observed the opposite. The brain pattern with long range connections are frequent in wakefulness. In addition, wakefulness is characterized by somewhat frequent temporal exploration of brain states. Our results show that analysis of functional connectivity patterns can be a useful tool for identifying specific and generalizable fingerprints of wakefulness and anaesthesia

Comments

Principal supervisor: Prof. Zhou Changsong (Hong Kong Baptist University)

Bibliography

Includes bibliographical references (pages 35-39)

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