Department of Biology
Small interfering RNA specific for N-methyl-D-aspartate receptor 2B offers neuroprotection to dopamine neurons through activation of MAP kinase
In the present study, N-methyl-D-aspartate receptor 2B (NR2B)-specific siRNA was applied in parkinsonian models. Our previous results showed that reduction in expression of N-methyl-D-aspartate receptor 1 (NR1), the key subunit of N-methyl-D-aspartate receptors, by antisense oligos amelio-rated the motor symptoms in the 6-hydroxydopamine (6-OHDA)-lesioned rat, an animal model of Parkinson's disease (PD).
Extracellular signal-regulated kinase signaling pathway, Motor symptom, N-methyl-D-aspartate receptor 2B, Parkinson's disease, Small interference RNA
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Ng, Olivia T.W., L. W. Chen, Y. S. Chan, and Ken K.L. Yung. "Small interfering RNA specific for N-methyl-D-aspartate receptor 2B offers neuroprotection to dopamine neurons through activation of MAP kinase." Neurosignals 21.2-1 (2013): 42-54.