Department of Chemistry
A coumarin-based fluorescent chemosensor CAQA has been synthesized. It can selectively and sensitively recognize Cu2+ in aqueous acetonitrile solutions. Using the Cu-containing complex CAQA-Cu2+ as a sensing ensemble, the device demonstrates highly selective recognition of His/biothiols and was applied in fluorescence imaging of histidine in hard-to-transfect living cells.
Source Publication Title
Royal Society of Chemistry
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Link to Publisher's Edition
You, Q., Lee, A., Chan, W., Zhu, X., & Leung, K. (2014). A coumarin-based fluorescent probe for recognition of Cu2+ and fast detection of histidine in hard-to-transfect cells by a sensing ensemble approach. Chemical Communications, 50 (47), 6207-6210. https://doi.org/10.1039/C4CC00521J