Department of Mathematics
Construction and analysis of single nucleotide polymorphism – single nucleotide polymorphism interaction networks
The study of gene regulatory network and protein-protein interaction network is believed to be fundamental to the understanding of molecular processes and functions in systems biology. In this study, the authors are interested in single nucleotide polymorphism (SNP) level and construct SNP-SNP interaction network to understand genetic characters and pathogenetic mechanisms of complex diseases. The authors employ existing methods to mine, model and evaluate a SNP sub-network from SNP-SNP interactions. In the study, the authors employ the two SNP datasets: Parkinson disease and coronary artery disease to demonstrate the procedure of construction and analysis of SNP-SNP interaction networks. Experimental results are reported to demonstrate the procedure of construction and analysis of such SNP-SNP interaction networks can recover some existing biological results and related disease genes. © 2013 The Institution of Engineering and Technology.
Source Publication Title
IET Systems Biology
Institution of Engineering and Technology
Link to Publisher's Edition
Liu, Yang, Xutao Li, Zhiping Liu, Luonan Chen, and Michael K. Ng. "Construction and analysis of single nucleotide polymorphism – single nucleotide polymorphism interaction networks." IET Systems Biology 7.5 (2013): 170-181.