School of Chinese Medicine
A metabolomics profiling study in hand-foot-and-mouth disease and modulated pathways of clinical intervention using liquid chromatography/quadrupole time-of-flight mass spectrometry
Hand-foot-and-mouth disease (HFMD), with poorly understood pathogenesis, has become a major public health threat across Asia Pacific. In order to characterize the metabolic changes of HFMD and to unravel the regulatory role of clinical intervention, we have performed a metabolomics approach in a clinical trial. In this study, metabolites profiling was performed by liquid chromatography/quadrupole time-of-flight mass spectrometry (LC-Q-TOF-MS) platform from the HFMD clinical patient samples. The outcome of this study suggested that 31 endogenous metabolites were mainly involved and showed marked perturbation in HFMD patients. In addition, combination therapy intervention showed normalized tendency in HFMD patients in differential pathway. Taken together, these results indicate that metabolomics approach can be used as a complementary tool for the detection and the study of the etiology of HFMD. © 2013 Cheng Lu et al.
Source Publication Title
Evidence-Based Complementary and Alternative Medicine
Hindawi Publishing Corporation
Link to Publisher's Edition
Lu, Cheng, Xinru Liu, Xiaorong Ding, Xiao Chen, Haiwei Fan, Yunqiang Liu, Ning Xie, Yong Tan, Joshua Ko, Weidong Zhang, and Aiping Lu. "A metabolomics profiling study in hand-foot-and-mouth disease and modulated pathways of clinical intervention using liquid chromatography/quadrupole time-of-flight mass spectrometry." Evidence-Based Complementary and Alternative Medicine 2013 (2013): 647452-1-647452-10.