School of Chinese Medicine
JCM-16021, a chinese herbal formula, attenuated visceral hyperalgesia in tnbs-induced postinflammatory irritable bowel syndrome through reducing colonic ec cell hyperplasia and serotonin availability in rats
The present study aimed to investigate the analgesic effect of JCM-16021, a revised traditional Chinese herbal formula, on postinflammatory irritable bowel syndrome (PI-IBS) in rats. The trinitrobenzene sulfonic (TNBS) acid-induced PI-IBS model rats were orally administrated with different doses of JCM-16021 (1.2, 2.4, and 4.8g/kg/d) for 14 consecutive days. The results showed that JCM-16021 treatment dose-dependently attenuated visceral hyperalgesia in PI-IBS rats. Further, the colonic enterochromaffin (EC) cell number, serotonin (5-HT) content, tryptophan hydroxylase expression, and mechanical-stimuli-induced 5-HT release were significantly ameliorated. Moreover, the decreased levels of mucosal cytokines in PI-IBS, especially the helper T-cell type 1- (Th1-) related cytokine TNF-α, were also elevated after JCM-16021 treatment. These data demonstrate that the analgesic effect of JCM-16021 on TNBS-induced PI-IBS rats may be medicated via reducing colonic EC cell hyperplasia and 5-HT availability. Copyright © 2012 Hong-Yan Qin et al.
Source Publication Title
Evidence-Based Complementary and Alternative Medicine
Hindawi Publishing Corporation
Link to Publisher's Edition
Qin, H., Xiao, H., Leung, F., Yang, Z., Wu, J., Sung, J., Xu, H., Tong, X., & Bian, Z. (2012). JCM-16021, a chinese herbal formula, attenuated visceral hyperalgesia in tnbs-induced postinflammatory irritable bowel syndrome through reducing colonic ec cell hyperplasia and serotonin availability in rats. Evidence-Based Complementary and Alternative Medicine, 2012, 1-12. https://doi.org/10.1155/2012/239638