Document Type
Journal Article
Department/Unit
School of Chinese Medicine
Language
English
Abstract
As part of our continuing efforts in the search for potential biologically active compounds from medicinal plants, we have isolated 18 compounds including two novel nitrogen containing diterpenes from extracts of the fruits of Vitex agnus-castus. These isolates, along with our previously obtained novel compound vitexlactam A (1), were evaluated for potential biological effects, including cancer chemoprevention. Chemically, the nitrogenous isolates were found to be two labdane diterpene alkaloids, each containing an α, β-unsaturated γ-lactam moiety. Structurally, they were elucidated to be 9α-hydroxy-13(14)-labden-16,15-amide (2) and 6β-acetoxy-9α- hydroxy-13(14)-labden-15,16-amide (3), which were named vitexlactams B and C, respectively. The 15 known isolates were identified as vitexilactone (4), rotundifuran (5), 8-epi-manoyl oxide (6), vitetrifolin D (7), spathulenol (8), cis-dihydro-dehydro-diconiferylalcohol-9-O-β-D-glucoside (9), luteolin-7-O-glucoside (10), 5-hydroxy-3,6,7, 4 ′ -tetramethoxyflavone (11), casticin (12), artemetin (13), aucubin (14), agnuside (15), β-sitosterol (16), p-hydroxybenzoic acid (17), and p-hydroxybenzoic acid glucose ester (18). All compound structures were determined/identified on the basis of 1D and/or 2D NMR and mass spectrometry techniques. Compounds 6, 8, 9, and 18 were reported from a Vitex spieces for the first time. The cancer chemopreventive potentials of these isolates were evaluated for NADP(H):quinone oxidoreductase type 1 (QR1) induction activity. Compound 7 demonstrated promising QR1 induction effect, while the new compound vitexlactam (3) was only slightly active.
Publication Date
2013
Source Publication Title
Evidence-Based Complementary and Alternative Medicine
Volume
2013
Start Page
432829-1
End Page
432829-7
Publisher
Hindawi Publishing Corporation
Peer Reviewed
1
Copyright
Copyright © 2013 Shenghong Li et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Funder
This work was in part supported by the “Hundred Talents Program” of the Chinese Academy of Sciences (awarded to Dr. S. Li).
DOI
10.1155/2013/432829
Link to Publisher's Edition
http://dx.doi.org/10.1155/2013/432829
ISSN (print)
1741427X
ISSN (electronic)
17414288
APA Citation
Li, S., Qiu, S., Yao, P., Sun, H., Fong, H., & Zhang, H. (2013). Compounds from the fruits of the popular European medicinal plant vitex agnus-castus in chemoprevention via NADP(H): Quinone qxidoreductase type 1 induction. Evidence-Based Complementary and Alternative Medicine, 2013, 432829-1-432829-7. https://doi.org/10.1155/2013/432829