Document Type

Journal Article

Department/Unit

School of Chinese Medicine

Title

Risk factors in development of motor complications in Chinese patients with idiopathic Parkinson’s disease

Language

English

Abstract

Motor complications induced by levodopa (L-dopa) treatment in Parkinson's disease (PD) are not well documented in patients of Chinese ethnicity. We performed a cross-sectional study to investigate the prevalence of dyskinesias and motor fluctuations, and the factors determining their development, in a population of Chinese patients with PD. Among 137 patients with PD, 98 (71.5%) had received a L-dopa preparation. Motor fluctuations were found in 74.5% and dyskinesias in 77.6% of the 98 patients. Patients with dyskinesias were younger at onset of disease than those without. Patients with dyskinesias and motor fluctuations had significantly longer duration of PD and L-dopa treatment, higher daily doses of L-dopa, and higher scores in the 39-item Parkinson's Disease Questionnaire (PDQ-39), when compared to patients without motor complications. Among these factors, motor fluctuations were best predicted by duration of L-dopa treatment and dyskinesias by disease duration. We conclude that motor complications are closely related to disease and treatment parameters, especially the treatment and disease duration. © 2008 Elsevier Ltd. All rights reserved.

Keywords

Chinese, cross-sectional study, Dyskinesias, Motor fluctuations, Parkinson's disease

Publication Date

2009

Source Publication Title

Journal of Clinical Neuroscience

Volume

16

Issue

8

Start Page

1034

End Page

1037

Publisher

Elsevier

DOI

10.1016/j.jocn.2008.10.015

Link to Publisher's Edition

http://dx.doi.org/10.1016/j.jocn.2008.10.015

ISSN (print)

09675868

ISSN (electronic)

15322653

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