School of Chinese Medicine
Radix Astragali (RA), known as Huangqi in China, is one of the most popular herbal medicines known worldwide to reinforce Qi. RA is traditionally prepared from the dried roots of Astragalus membranaceus (MJHQ) and A. membranaceus var. mongholicus (MGHQ). Radix Hedysari is named Hongqi (HQ), which is similar to RA. We assessed and compared the chemical constituents and bioactivity of RA and HQ. Different constituents were extracted into five major parts and were analyzed using different methods. Comparison of the immunological effects of extracts was done by using two immunological models. Results showed that flavonoids and saponins present in RA and HQ were not only structurally significantly different but also different in their immunological effect. Amino acids extract (AE) in MGHQ shows immunological effect while AE in MJHQ and HQ did not. Polysaccharides comprised the major constituents in RA and HQ. All polysaccharides extract (PE) of the three herbs showed similar levels of immunological effect in both immunological assays.
Source Publication Title
Journal of Biomedicine and Biotechnology
Article ID 479426
Hindawi Publishing Corporation
© 2010 Jing Liu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
This project was supported by the Faculty Research Grant of Hong Kong Baptist University (FRG/06-07/II-24).
Link to Publisher's Edition
Chen, Hubiao, Jing Liu, Xuguang Hu, Quan Yang, Zhiling Yu, Zhongzhen Zhao, and Tao Yi. "Comparison of the immunoregulatory function of different constituents in Radix Astragali and Radix Hedysari." Journal of Biomedicine and Biotechnology 2010 (2010): Article ID 479426.